Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 20512생성일: 2026년 10월 25일
Potassium Carbonate → 3-{[4-(Azetidin-1-ylcarbonyl)-2-chlorophenyl]oxy}-5-{[(1S)-2-hydroxy-1-methylethyl]oxy}N-(1-methyl-1H-pyrazol-3-yl)benzamide
https://huagongshe.com/reaction/20512
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide | HCID 53629632 | — |
| 반응물 | (Azetidin-1-yl)(3-chloro-4-fluorophenyl)methanone | HCID 59346868 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-{[4-(Azetidin-1-ylcarbonyl)-2-chlorophenyl]oxy}-5-{[(1S)-2-hydroxy-1-methylethyl]oxy}N-(1-methyl-1H-pyrazol-3-yl)benzamide | HCID 11583909 | 50.6% |
반응 단계
To a mixture of 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyloxy)-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide (215 mg, 0.53 mmol) and 1-(3-chloro-4-fluorobenzoyl)azetidine (135 mg, 0.63 mmol) in DMF (2.0 mL) was added potassium carbonate (146 mg, 1.06 mmol) and the stirred mixture heated at 160° C. in a ‘Smith Creator Microwave’ for 120 minutes. The mixture was allowed to reach ambient temperature and pressure then reduced in volume. Purification by column chromatography, eluting with 0-20% methanol in DCM, afforded the title compound (130 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07745475B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-4743b5858cab40b8ba84b36945f18bf5 |
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| 출처 메모 | uspto-grants-2010_06 |
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