反应详情

A mixture of potassium-t-butoxide (5 g) in 100 ml t-butanol is heated to reflux. A solution of 3-oxo-17β-(hydroxymethyl)-4-androstene (10 g) in t-butanol is added followed by a solution of methyl iodide (2.7 g) in t-butanol. Heating is continued for 3 hours. The mixture is then cooled, acidified, and extracted with dichloromethane. The dichloromethane solution is washed with brine, dried, and concentrated to yield 3-oxo-17β-(hydroxymethyl)-4-methyl-4-androstene.

1. temperatureis heated to reflux
2. temperatureHeating
3. temperatureThe mixture is then cooled
4. extractionextracted with dichloromethane
5. washThe dichloromethane solution is washed with brine
6. customdried
7. concentrationconcentrated