Water → HCID 67946076, compound

Participants

Reaction Conditions

Reaction Steps

12 g of sodium hydroxide are added to a solution of 70 g of triazole in 300 ml of N-methylpyrrolidone and the mixture is heated for 30 minutes at 50° C. Thereafter, 73 g of 2-(4-chlorophenyl)-2-(1-methyl-2-[2-chlorophenyl]-ethenyl)-oxirane, dissolved in 100 ml of N-methylpyrrolidone, are slowly added dropwise at room temperature. The reaction mixture is stirred for 15 hours at room temperature after which 300 ml of water are added to the solution and the mixture is extracted several times by shaking with methyl tert-butyl ether. The organic phase isolated is washed twice with water and then dried over sodium sulfate and evaporated down. Crystallization of the residue from methyl tert-butyl ether/n-hexane gives 85 g (95%) of 1-(1,2,4-triazol-1-ylmethyl)-1-(4-chlorophenyl)-2-methyl-3-(2-chlorophenyl)-propenol of melting point 141°-143° C.

Provenance & Evidence