HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-3-nitrobenzyl alcohol → (3-Amino-2-methylphenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-3-nitrobenzyl alcohol | HCID 90289 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (3-Amino-2-methylphenyl)methanol | HCID 577175 | 90.2% |
Reaction Steps
A solution of 2-methyl-3-nitrobenzenemethanol (10.0 g, 59.8 mmol) in methanol is treated with Raney Nickel and shaken under hydrogen gas (50 psi) in a Parr Shaker. The solution is filtered through Celite and evaporated. Recrystallization of the residue from isopropyl ether gives pure 3-amino-2-methylbenzenemethanol (7.4 g, 90%), mp=106-108° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05017604 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-d8b1fd7509a24476979881ec20c3dea0 |
| Source note | uspto-grants-1991_05 |