Hydrochloric Acid → HCID 19762618, compound

Participants

Reaction Steps

2-[[3-[1-(Acetylhydroxyamino)ethyl]-2-chlorophenyl]amino]benzoic acid methyl ester (0.24 g, 0.7 mmol) is suspended in 150 mL of 1 N potassium hydroxide containing 10 mL methanol. The reaction mixture is stirred until all the solid is dissolved (about 2 hours). It is acidified to pH=1 with concentrated HCl and the resulting precipitate is collected by filtration. Recrystallization from ethyl acetate gives 2-[[3-[1-[acetylhydroxyamino)ethyl]-2-chlorophenyl]amino]benzoic acid (74 mg, 32 %) as a hydrate. mp=162-164° C. dec.

Provenance & Evidence