Isopropylamine → HCID 86744781, compound

Participants

Reaction Steps

In a 200 mL round-bottomed flask were placed 3-chloro-1-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanone oxime 4b (3.53 g, 12.1 mmole), isopropylamine (3.56 g, 60.3 mmole), and THF (71 mL). The mixture was stirred at room temperature for 2.5 hours. The reaction mixture was concentrated in vacuo at room temperature. The residue was triturated with isopropyl ether and precipitated crystals were filtered with suction. The crystals were dissolved in dil. HCl solution. To the solution were added ether and NaHCO3 in small portions under vigorous stirring conditions. The organic layer was washed with water and dried over anyydrous MgSO4, and concentrated in vacuo. Yield: 0.42 g (11.6%) from isopropyl ether.

Provenance & Evidence