Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | N-(2-Chloroethyl)-N'-[2-(3-pyridinecarbonyloxy)ethyl]-N-nitrosourea | HCID 15680044 | — |
Reaction Steps
A solution of the product of Example 122 (1.5 g. 5 mmol) in 40 mL of tetrahydrofuran was treated with excess methyl iodide. The mixture was stirred at 50° C. for 4 hours. The finely crystalline, yellow solid thus obtained (1.8 g, 82%) melted at 120°-121° C. and had the structure ##STR150## as confirmed by elemental analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05017566 |
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| Source dataset | uspto-grants-1991_05 |
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| ORD ID | ord-2b068bfa72554917ac593f2e998f5727 |
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| Source note | uspto-grants-1991_05 |
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