Aniline → Formanilide

HRID 2051321Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:8][O:9]C([C@@H](NC([C@@H](N)CC(O)=O)=O)CC1C=CC=CC=1)=O>>[CH:8]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:9]

Participants

Reactant 2

HCID 6115Aniline

HCID 134601Aspartame

Product 1

HCID 7671FormanilideYield 65%

Procedure

The reaction was run as described in Example 1, however, 0.70 g (7.6 mmol) aniline was used. Analysis of the reaction showed that aspartame was formed in 65-70% yield. Formanilide was also formed.

Workup

customwas formed in 65-70% yield

Sources & evidence

ORD record: ord-f332b71b4ccc4d3e9bc5363d16835240
Source dataset: uspto-grants-1991_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05017690

Reaction notes

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