1,3-Propanediol, 2-(2-iodoethyl)-, diacetate → HCID 19833374, compound

HRID 2051361Notes

Reaction equation

HRID 2051361 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([S:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)[N:3]=1.[C:20]([O:23][CH2:24][CH:25]([CH2:29][O:30][C:31](=[O:33])[CH3:32])[CH2:26][CH2:27]I)(=[O:22])[CH3:21]>>[C:20]([O:23][CH2:24][CH:25]([CH2:29][O:30][C:31](=[O:33])[CH3:32])[CH2:26][CH2:27][N:6]1[C:5]2[C:9](=[N:10][C:2]([NH2:1])=[N:3][C:4]=2[S:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)[N:8]=[CH:7]1)(=[O:22])[CH3:21]

Participants

3

Reactant 2

HCID 1539121,3-Propanediol, 2-(2-iodoethyl)-, diacetateHCID 9408016-[(4-methylphenyl)methylsulfanyl]-7H-purin-2-amine

Product 1

HCID 19833374HCID 19833374, compoundYield 10%

Procedure

Using the previously described procedure 2-amino-6- [(4-methylphenyl)methylthio]purine (25 g) and 2-acetoxymethyl-4-iodobut-1-yl acetate (29 g) gave the title compound 33.3 g (79%) m.p. 102°-103°, and 4.2 g (9.9%) of 7-(4-acetoxy-3-acetoxymethylbut-1-yl)-2- amino-6-[(4-methylphenyl)methylthio]purine

Sources & evidence

ORD record
ord-0fb0be8ac5674d76a962e5eb97cfc9da
Source dataset
uspto-grants-1991_05
Patent number
US05017701

Reaction notes

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