2,2,3,6-Tetramethylcyclohexanone → 1,2,2,4-Tetramethyl-3-methylene-cyclohexane

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Reaction Steps

The present invention provides a process for the preparation of 4,4,5,8-tetramethyl-1-oxaspiro[2.5]octane which compound can then be converted into useful 2,2,3,6-tetramethyl-cyclohexane-carbaldehyde by treating it with a Lewis type acid. The aldehyde thus obtained possesses a high degree of isomeric purity (equal or higher than 90%). The process of the invention consists in the methylenation of 2,2,3,6-tetramethyl-1-cyclohexanone to give 1,2,2,4-tetramethyl-3-methylene-cyclohexane followed by the epoxidation of the obtained compound to give 4,4,5,8-tetramethyl-1-oxaspiro[2.5]octane.

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