反应详情

6.0 Grams of sodium borohydride was added to a solution prepared by dissolving 15.0 g of 5,7-dimethyl-8-methoxy-1,2,3,4,4a,9a-hexahydro-9-fluorenone in 300 ml of methanol and 50 ml of water and reaction was effected under ice-cooling for 4 hours. The solvent was distilled off and the residue was extracted with dichloromethane and then the extract was washed twice with saturated sodium chloride solution. Then, this was dried with magnesium sulfate and the solvent was distilled off to obtain 16.1 g of 5,7-dimethyl-8-methoxy-9-hydroxy-1,2,3,4,4a,9a-hexahydrofluorene.

1. customprepared
2. dissolutionby dissolving
3. temperaturecooling for 4 hours
4. distillationThe solvent was distilled off
5. extractionthe residue was extracted with dichloromethane
6. washthe extract was washed twice with saturated sodium chloride solution
7. dry with materialThen, this was dried with magnesium sulfate
8. distillationthe solvent was distilled off