Ethanol → Ninhydrin

Participants

Reaction Steps

1.0 Gram of 7-amino-8-hydroxy-5-methyl-1,2,3,4,4a,9a-hexahydro-9-fluorenone was dissolved in 30 ml of ethanol and 0.5 ml of acetic anhydride was added. The solution was stirred at room temperature for 1 hour. After disappearance of the color formed by ninhydrin was confirmed on a thin-layer chromatography, the reaction mixture was concentrated. To the residue was added diisopropyl ether and the resulting precipitate was collected by filtration to obtain 0.8 g of 7-acetylamino-8-hydroxy-5-methyl-1,2,3,4,4a,9a-hexahydro-9-fluorenone (light brown crystal).

Provenance & Evidence