Phosphate → HCID 14549129, compound

HRID 2051448Notes

Reaction equation

HRID 2051448 reaction equation
C([O:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:20])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)[CH3:6])(=O)C.P([O-])([O-])([O-])=O>C(Cl)(Cl)Cl>[OH:4][CH:5]([C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:20])=[CH:15][CH:14]=2)=[CH:11][CH:12]=1)[CH3:6]

Participants

4

Reactant 2

HCID 1061PhosphateHCID 14534380HCID 14534380, compound

Product 1

HCID 14549129HCID 14549129, compoundYield 39.9%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

29.9 g (0.08 mol) of IV-15 was mixed with 800 ml of 0 1 M phosphate buffer (pH 7.5), 30 ml of chloroform and 6 g of Amano Lipase P and the mixture was stirred vigorously at 30°-35° C. for 20 hours. The reaction mixture was extracted with 600 ml of methyl isobutyl ketone. The organic layer was concentrated under reduced pressure and the residue was purified by column chromatography using a 12:1 mixed solution of chloroform and ethyl acetate as eluting solvent to obtain 10.6 g of (+)-benzyl 4'-(1-hydroxyethyl)-4-biphenylcarboxylate (V-15). [α]D25 =+23.7° (c=1, CHCl3), m.p.=104°-106° C.

Workup

  1. extractionThe reaction mixture was extracted with 600 ml of methyl isobutyl ketone
  2. concentrationThe organic layer was concentrated under reduced pressure
  3. customthe residue was purified by column chromatography
  4. washas eluting solvent

Sources & evidence

ORD record
ord-3c6786ded2774fa09a34007aed910713
Source dataset
uspto-grants-1991_05
Patent number
US05019298

Reaction notes

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