Tetrahydrofuran → HCID 14597184, compound

Participants

Reaction Steps

1.03 g (2.8 mmol) of VII-15, 0.1 g of 5% Pd-C, 15 ml of tetrahydrofuran and 5 ml cf methanol were mixed and the mixture was subjected to catalytic hydrogenation under normal pressure. When the hydrogen absorption reached 66 ml, the reaction was stopped and the catalyst was filtered away. The filtrate was concentrated and purified by column chromatography to obtain 0.76 g (98% yield) of (+)-4'-(1-octyloxyethyl)4-biphenylcarboxylic acid. [α]D25 =+67.5° (c=1, CHCl3), m.p.=139°-140° C.

Provenance & Evidence