HCID 14986016, compound → HCID 14986017, compound

Participants

Reaction Steps

The 2-ethylamino-3-morpholino-4-nitroquinoline (2.0 g, 0.0066 mol) was dissolved in tetrahydrofuran (10 ml) and subjected to reduction in the presence of 10g palladium-on-carbon (0.3 g). After completion of the reaction, the palladium-on-carbon catalyst was filtered off and the mother liquor was concentrated. Following purification by chromatography on an alumina column using chloroform as a developing solvent, recrystallization from ethanol gas conducted, whereupon 4-amino-2-ethylamino-3-morpholinoquinoline was obtained in an amount of 1.2 g (yield, 67%).

Provenance & Evidence