Pyridine → HCID 14986018, compound

HRID 2051476Notes

Reaction equation

HRID 2051476 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:8]=[N+:9]([O-])[C:10]3[C:15]([C:16]=2[N+:17]([O-:19])=[O:18])=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:3][CH2:2]1.N1C=CC=CC=1.C(OC(=O)C)(=[O:29])C>>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8](=[O:29])[NH:9][C:10]3[C:15]([C:16]=2[N+:17]([O-:19])=[O:18])=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 14986012HCID 14986012, compound

Product 1

HCID 14986018HCID 14986018, compound

Procedure

The 3-morpholino-4-nitroquinoline-N-oxide (4 g, 0.015 mol) obtained in Example 5-(b) was dissolved in acetic anhydride (20 ml) and pyridine (20 ml) and the solution was heated on an oil bath at 80° C. for 3 hours. Excess acetic anhydride and pyridine were distilled off from the whole reaction mixture in vacuum and the residue was washed with ether to obtain 3-morpholino-4-nitro-2-quinolone in an amount of 3.5 g (yield, 88%),

Workup

  1. distillationExcess acetic anhydride and pyridine were distilled off from the whole reaction mixture in vacuum
  2. washthe residue was washed with ether

Sources & evidence

ORD record
ord-a297a05fd60c4492a7202ae581f85c70
Source dataset
uspto-grants-1991_05
Patent number
US05019574

Reaction notes

Loading…