HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 12471526, compound → HCID 14986024, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 12471526 | HCID 12471526 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 14986024 | HCID 14986024 | — |
Reaction Steps
The 4-nitro-3-piperidinoquinoline-N-oxide (4 g, 0.015 mol) was dissolved in a mixed solvent of methanol and tetrahydrofuran (50 ml) and subjected to catalytic reduction in the presence of purified Raney nickel (2 ml). Upon isolation and purification by chromatography on an alumina column (developing solvent: CHCl3), 4-amino-3-piperidinoquinoline was obtained in an amount of 2.1 g (yield, 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05019574 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-4391a8d33fb44356b94cc692a9376c38 |
| Source note | uspto-grants-1991_05 |