1-Methylcyclopropanamine → HCID 14988395, compound

Participants

Reaction Steps

A solution of 375 mg (2.31 mmol) of (R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane and 950 mg of (1-methylcyclopropyl)amine in 1 ml of absolute ethanol was heated at 70° C. for 4 hours in a sealed reaction tube. The reaction mixture was concentrated under reduced pressure and the residue chromatographed on silica gel plates (95:5:1 methylene chloride: methanol:conc. ammonium hydroxide) to give 338 mg of product, m.p. 72°-73° C.

Provenance & Evidence