(R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane → HCID 14988403, compound

Participants

Reaction Steps

A solution of (R)-2-(tetrazolo[1,5-a]pyrid-6-yl)oxirane (375 mg, 2.31 mmol) and (3,3-dimethylcyclobutyl)amine (1.14 g, 11.5 mmol) in 0.8 ml of absolute ethanol was heated at 70° C. in a sealed reaction vessel for 3 hours. The reaction mixture was concentrated and the residue was purified by preparative Tlc on silica gel (90:10:1 methylene chloride:methanol:NH4OH) to give 628 mg of product; Analysis: Calc'd. for C13H19N5O:

Provenance & Evidence