Cyclopentylamine → HCID 14988405, compound

Participants

Reaction Steps

A solution of 250 mg (1.54 mmol) of (R)-2-(tetrazolo[1,5-a]pyrid-6-yl)oxirane and 0.751 ml (7.61 mmol) of cyclopentyl amine in 0.6 ml of absolute ethanol was heated at 100° C. for 3 hours in a sealed reaction tube. The reaction mixture was concentrated to dryness and the residue (375 mg) purified by preparative Tlc on silica gel (90:10:2 ethyl acetate: methanol:triethylamine) to give 287 mg of pure product.

Provenance & Evidence