HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentanamine, 1-methyl- → HCID 14988407, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentanamine, 1-methyl- | HCID 520998 | — |
| Reactant | (R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane | HCID 13090314 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 14988407 | HCID 14988407 | 62.1% |
Reaction Steps
A solution of (R)-2-(tetrazolo[1,5-a]pyrid-6-yl)oxirane (375 mg, 2.31 mmol) and (1-methylcyclopentyl)amine (229 mg, 2.31 mmol) in 10 ml of absolute ethanol was heated at reflux for 20 hours. The reaction mixture was concentrated to dryness and the residue (532 mg) purified by preparative Tlc on silica gel (90:10:1 methylene chloride:methanol: NH4OH) to afford 375 mg of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05019578 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-1c4cd1a1b3214de4968c5040c52b5ab7 |
| Source note | uspto-grants-1991_05 |