Sodium Hydroxide → HCID 19832228, compound

HRID 2051509Notes

Reaction equation

HRID 2051509 reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:20])[CH2:7][CH2:8][C:9]1([CH3:19])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH2:11][CH2:10]1)C>O.C(O)C>[CH3:19][C:9]1([CH2:8][CH2:7][C:6]([OH:20])=[O:5])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH2:11][CH2:10]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 53946144HCID 53946144, compound

Product 1

HCID 19832228HCID 19832228, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 14 g NaOH in 60 ml of water was added to a solution of 21 g of 5 in 600 ml ethanol. The mixture was stirred for 2 hours. The bulk of the ethanol was then evaporated and the residue poured into 1 liter of water. The mixture was acidified with 2N HCl and the product extracted with ether. The organic layer was dried and evaporated. This yielded 17.5 g of carboxylic acid 6 in the form of an oil; Rf =0.47 (toluene/ethyl acetate/ethanol/acetic acid 8/2/1/0 1).

Workup

  1. customThe bulk of the ethanol was then evaporated
  2. additionthe residue poured into 1 liter of water
  3. extractionthe product extracted with ether
  4. customThe organic layer was dried
  5. customevaporated

Sources & evidence

ORD record
ord-a411c639d0bc4dd78a8de4493ec6d8df
Source dataset
uspto-grants-1991_05
Patent number
US05019585

Reaction notes

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