Sodium Hydroxide → HCID 14987156, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of cis-1-methoxycarbonyl-3-methyl-4-[(1-oxo-propyl)-2-fluorophenylamino]-piperidine (3.2 g, 9.89 mmol) in 48% aqueous HBr (20 ml) is refluxed for two hours. Upon heating the mixture dissolution occurs. The solution is cooled to 0° C. and 5N NaOH is added until the pH is between 11 and 12. The aqueous phase is extracted with methylene chloride (5×) and the combined organics dried over sodium sulfate and concentrated to give cis-3-methyl-4-(2-fluorophenylamino)-piperidine as an oil: 2.0 g; 97%.

Provenance & Evidence