HCID 14987158, compound → HCID 14987159, compound

Participants

Reaction Steps

A mixture of cis-1-benzyloxycarbonyl-3-methyl-4-[(1-oxopropyl)-2-fluorophenylamino]-piperidine (576 mg, 1.45 mmol) and 10% Pd-C (100 mg) in methanol (25 ml) and acetic acid (5 ml) is hydrogenated at 50 psi for five hours. The reaction mixture is filtered through celite and the filtrate is concentrated. The residue is diluted with ethyl acetate, basified to pH 11 with 2N NaOH and shaken. The separated organics are dried over sodium sulfate and concentrated to give cis-3-methyl-4-[(1-oxopropyl)-2-fluorophenylamino]piperidine as an oil: 333 mg; 87%.

Provenance & Evidence