4-Fluoroaniline → HCID 19832326, compound

HRID 2051537Notes

Reaction equation

[CH3:1][C:2]1([CH3:17])[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=O)=[CH:8][CH:9]=2)[N:4]([CH2:14][CH3:15])[C:3]1=[O:16].[F:18][C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=1>>[CH3:17][C:2]1([CH3:1])[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH:23][C:22]3[CH:24]=[CH:25][C:19]([F:18])=[CH:20][CH:21]=3)=[O:13])=[CH:8][CH:9]=2)[N:4]([CH2:14][CH3:15])[C:3]1=[O:16]

Participants

Reactant 2

HCID 97314-Fluoroaniline

HCID 19938586HCID 19938586, compound

Product 1

HCID 19832326HCID 19832326, compoundYield 58%

Procedure

By reaction of the 2,3-dihydro-3,3-dimethyl-1-ethyl-2-oxo-(1H)-indole-6-carboxylic acid prepared in Example 34b with 4-fluoroaniline analogously to Example 1c, there was obtained the title compound in a yield of 58% of theory; m.p. 179°-181° C., after recrystallisation from ethyl acetate.

Sources & evidence

ORD record: ord-fac01f6127df47ce9660b377eff5ae31
Source dataset: uspto-grants-1991_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05019587

Reaction notes

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