Dimethylformamide → HCID 19832360, compound

Participants

Reaction Steps

2.8 g. (10 mmol) 2,3-Dihydro-3,3-dimethyl-N-phenyl-2-oxo-(1H)-indole-6-carboxamide, 2.8 g. (20 mmol) methyl iodide and 2.5 g. (20 mmol) potassium carbonate were stirred in 50 ml. dimethylformamide for 3 hours at 70° C. After cooling, the reaction mixture was mixed with water, decanted and again mixed with water. The residue was purified by column chromatography (RP-18, methanol:water:ammonium hydroxide 80:20:1 v/v/v). Pure fractions were evaporated until the commencement of crystallisation, subsequently filtered off with suction and washed with water. There were obtained 2.3 g. (78% of theory) of the title compound; m.p. 184-186° C.

Provenance & Evidence