Acetic Anhydride → HCID 67835692, compound

Participants

Reaction Steps

0.83 g. (2.4 mmol) 2,3-Dihydro-3,3-dimethyl-N-(4-aminophenyl)-2-oxo-(1H)-indole-6- carboxamide (from Example 29) was stirred in 5 ml. 2N acetic acid and ml. (53.4 mmol) acetic anhydride for 3 hours at 40° C. The solvent was removed under vacuum and the residue purified by column chromatography (silica gel; isohexane:ethyl acetate:methanol 5:4:0.5 v/v/v) to give 0.6 g. (63% of theory) of the title compound; m.p. 294-295° C.

Provenance & Evidence