Benzoyl chloride → HCID 22809669, compound

HRID 2051612Notes

Reaction equation

HRID 2051612 reaction equation
[SeH:1][CH2:2][CH2:3][C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])=[O:5].[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>N1C=CC=CC=1>[O:5]=[C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])[CH2:3][CH2:2][Se:1][C:14](=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 101779737HCID 101779737, compound

Product 1

HCID 22809669HCID 22809669, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a chilled solution of 0.5 g. of 1-(3-selenyl-1-oxopropyl)-L-proline dissolved in 5 ml. of pyridine there is added dropwise with stirring 0.3 g. of benzoyl chloride. The mixture is allowed to come to room temperature. After three hours, the solvent is evaporated. The residue is taken up in ethyl acetate, washed with saturated sodium bicarbonate solution and then with water. The solvent is dried, and evaporated to yield 1-[1-oxo-3-[(benzoyl)-selenyl]propyl]-L-proline.

Workup

  1. customto come to room temperature
  2. customthe solvent is evaporated
  3. washwashed with saturated sodium bicarbonate solution
  4. customThe solvent is dried
  5. customevaporated

Sources & evidence

ORD record
ord-98a24c1deac74e8497691f5f6cb958b5
Source dataset
uspto-grants-1980_01
Patent number
US04181663

Reaction notes

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