Ethanol → 1-(2H-3-chromenyl)-3-(N-methyl-piperazino)-1-propanone hydrochloride

Participants

Reaction Steps

3-Acetyl-2H-chromene (0.5 mole) is dissolved in 250 ml ethanol, while warming. N-methyl-piperazine hydrochloride (0.4 mole) in ethanol (250 ml) and concentrated hydrochloric acid (1 ml) are added thereto. Trioxymethylene (3 moles) is added portionwise over 2 hours, and the resulting material is refluxed overnight. A pale yellow precipitate forms gradually. After cooling, the precipitate is filtered off, washed with ethanol and then with ether, after which it is dried in a desiccator at 90° C. and recrystallized from the minimum amount of water. M.p.=228° C.

Provenance & Evidence