HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl pyruvate → 2-Hydroxy-3,6,7-trimethylquinoxaline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl pyruvate | HCID 12041 | — |
| Reactant | 4,5-Dimethyl-1,2-phenylenediamine | HCID 76635 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Hydroxy-3,6,7-trimethylquinoxaline | HCID 247489 | — |
Reaction Steps
4,5-Dimethyl-o-phenylenediamine (10.0 g., 0.073 mol.) was dissolved in tetrahydrofuran (200 ml.) and ethyl pyruvate (12.75 g., 0.11 mol.) added. The reaction mixture was stirred at room temperature for eighteen hours, during which time a white solid precipitated was collected by filtration (13.35 g.). Recrystallization from methanol-chloroform gave fine white needles. (12.65 g., m.p. 306-308°, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04181724 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-b7a23e633b0f4040b7a410f536369942 |
| Source note | uspto-grants-1980_01 |