HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → Tetrahydro-N-methyl-N-(phosphonomethyl)-3-thiophenamine 1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphorous acid | HCID 107909 | — |
| Reactant | 3-(Methylamino)-1lambda6-thiolane-1,1-dione hydrochloride | HCID 2770817 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Tetrahydro-N-methyl-N-(phosphonomethyl)-3-thiophenamine 1,1-dioxide | HCID 20509047 | 86.3% |
Reaction Steps
A mixture of N-methyltetrahydro-3-thiophenamine 1,1-dioxide hydrochloride (37.2 parts, 0.20 mole); 90 percent paraformaldehyde (6.8 parts, 0.22 mole); orthophosphorous acid (18.0 parts, 0.22 mole); and water (30 parts) was heated at its reflex temperature for 3 hours. After cooling, the solution was stirred into ethanol (150 ml.) and the sticky, white precipitate was triturated under more ethanol. After being dried in vacuo over P2O5 the product weighed 42.0 g. (86.3 percent yield). m.p. 222°-225° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04181806 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-5da9cf5125984a4f8fe5fd7dcf6c9322 |
| Source note | uspto-grants-1980_01 |