2,5-Dichloronitrobenzene → HCID 20379503, compound

Participants

Reaction Steps

A mixture of 52.5 parts of α-methyl-3-pyridinemethanamine, 84.5 parts of 1,4-dichloro-2-nitrobenzene, 53 parts of sodium carbonate and 320 parts of 1-butanol is stirred and refluxed for 72 hours. The reaction mixture is evaporated and water is added to the residue. The oily product is extracted with methylbenzene. The extract is dried, filtered and evaporated. The residue is converted into the hydrochloride salt in 2,2'-oxybispropane, 4-methyl-2-pentanone and 2-propanol. The oily salt is separated and crystallized from 2-propanol, yielding 46 parts (34%) of N-(4-chloro-2-nitrophenyl)-α-methyl-3-pyridinemethanamine monohydrochloride.

Provenance & Evidence