Water → HCID 20379499, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 41.5 parts of 4-chloro-N1 -[1-(3-pyridinyl)ethyl]-1,2-benzenediamine monohydrochloride and 27 parts of urea is stirred and heated for 1.50 hours in an oil-bath at about 190° C. The reaction mixture is cooled, water and trichloromethane are added and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is crystallized from a mixture of 4-methyl-2-pentanone and 2,2'-oxybispropane. The product is filtered off and dried, yielding 26 parts (63.5%) of 5-chloro-1,3-dihydro-1-[1-(3-pyridinyl)ethyl]-2H-benzimidazol-2-one; mp. 190° C.

Provenance & Evidence