Sodium Acetate → HCID 20379506, compound

Participants

Reaction Steps

A mixture of 24 parts of 5-chloro-1,3-dihydro-1-[1-(3-pyridinyl)ethyl]-2H-benzimidazol-2-one, 10 parts of sodium acetate and 400 parts of acetic acid is hydrogenated at normal pressure and at a temperature of 60° C. with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is taken up in water and the whole is alkalized with concentrated ammonium hydroxide. The product is extracted three times with 300 parts of trichloromethane. The combined extracts are dried, filtered and evaporated, yielding 22 parts (100%) of 1,3-dihydro-1-[1-(3-piperidinyl)ethyl]-2H-benzimidazol-2-one as an oily residue.

Provenance & Evidence