反应详情

A mixture of 16 parts of 1,3-dihydro-1-methyl-3-(3-pyridinylmethyl)-2H-benzimidazol-2-one and 200 parts of acetic acid is hydrogenated at normal pressure and at 50° C. with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. Water is added to the residue and the whole is alkalized with ammonium hydroxide. The product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 16.5 parts (100%) of 1,3-dihydro-1-methyl-3-(3-piperidinylmethyl)-2H-benzimidazol-2-one as an oily residue.

1. filtrationthe catalyst is filtered off
2. customthe filtrate is evaporated
3. additionWater is added to the residue
4. extractionThe product is extracted with methylbenzene
5. customThe extract is dried
6. filtrationfiltered
7. customevaporated