反应详情

To a stirred mixture of 20 parts of 1-(2-hydroxy-5-methylphenyl)ethanone, 50.5 parts of (chloromethyl)oxirane and 40 parts of methanol are added dropwise 25 parts of sodium methoxide solution 30%. Upon completion, stirring is continued for 1 hour at room temperature. The reaction mixture is filtered and the filtrate is evaporated. The residue is dissolved in methylbenzene. The latter is washed with water, dried, filtered and evaporated. The residue is distilled, yielding 15 parts (55%) of 1-[5-methyl-2-(oxiranylmethoxy)phenyl]ethanone; bp. 140°-150° C. at 0.3 mm. pressure.

1. filtrationThe reaction mixture is filtered
2. customthe filtrate is evaporated
3. dissolutionThe residue is dissolved in methylbenzene
4. washThe latter is washed with water
5. customdried
6. filtrationfiltered
7. customevaporated
8. distillationThe residue is distilled