Sodium Carbonate → HCID 53996252, compound

Participants

Reaction Steps

A mixture of 4 parts of (4-chlorophenoxymethyl)oxirane, 5 parts of 1,3-dihydro-1-(3-pyrrolidinylmethyl)-2H-benzimidazol-2-one monohydrochloride, 6 parts of sodium carbonate and 80 parts of 2-propanol is stirred and refluxed for 5 hours. The reaction mixture is cooled, filtered and the filtrate is evaporated. The residue is crystallized from 4-methyl-2-pentanone, yielding 2.8 parts (35%) of 1-{1-[3-(4-chlorophenoxy)-2-hydroxypropyl]-3-pyrrolidinylmethyl}-1,3-dihydro-2H-benzimidazol-2-one; mp. 129° C.

Provenance & Evidence