Pyridine → HCID 86736764, compound

HRID 2051699Notes

Reaction equation

HRID 2051699 reaction equation
[O:1]=[C:2]1[CH:5]([N:6]2[C:10](=[O:11])[C:9]3=[CH:12][CH:13]=[CH:14][CH:15]=[C:8]3[C:7]2=[O:16])[CH2:4][N:3]1[CH:17]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:18]([O:20][CH3:21])=[S:19].N1C=CC=CC=1.S(Cl)(Cl)(=O)=O>ClCCl>[O:1]=[C:2]1[CH:5]([N:6]2[C:7](=[O:16])[C:8]3=[CH:15][CH:14]=[CH:13][CH:12]=[C:9]3[C:10]2=[O:11])[CH2:4][N:3]1[C:17](=[CH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:18]([O:20][CH3:21])=[S:19]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24648Sulfuryl chlorideHCID 54440053HCID 54440053, compound

Product 1

HCID 86736764HCID 86736764, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Methyl 2-(2-oxo-3-phthalimido-1-azetidinyl)-3-phenylthiopropionate (5.1 g.) and pyridine (4.0 g.) were dissolved in dichloromethane (100 ml.), and to the solution, there was added dichloromethane (20 ml.) solution containing sulfuryl chloride (2.0 g.) at 35° to 40° C. in the course of 70 minutes with stirring. The stirring was continued at the same temperature for an hour. After the reaction, the reaction mixture was evaporated to dryness under reduced pressure. Ethyl acetate (100 ml.) and water (50 ml.) were added to the residue obtained, and the resultant mixture was stirred for a while. The ethyl acetate layer was separated from the mixture and the remaining aqueous solution was extracted with ethyl acetate. This extract and the above ethyl acetate layer were combined, washed with three portions of diluted hydrochloric acid, three portions of saturated aqueous sodium bicarbonate, two portions of water and then dried over magnesium sulfate. The solvent was removed by distillation from the solution under reduced pressure to give an oily residue (4.95 g.), which was subjected to column chromatography on silica gel(30 g.). Elution was carried out with chloroform and the fractions containing a desired compound were collected. The solvent was removed by distillation from the solution under reduced pressure to give methyl 2-(2-oxo-3-phthalimido-1-azetidinyl)-3-phenylthioacrylate (a mixture of trans and cis isomer) (4.23 g.).

Workup

  1. waitThe stirring was continued at the same temperature for an hour
  2. customAfter the reaction
  3. customthe reaction mixture was evaporated to dryness under reduced pressure
  4. additionEthyl acetate (100 ml.) and water (50 ml.) were added to the residue
  5. customobtained
  6. customThe ethyl acetate layer was separated from the mixture
  7. extractionthe remaining aqueous solution was extracted with ethyl acetate
  8. extractionThis extract
  9. washwashed with three portions of diluted hydrochloric acid, three portions of saturated aqueous sodium bicarbonate, two portions of water
  10. dry with materialdried over magnesium sulfate
  11. customThe solvent was removed by distillation from the solution under reduced pressure
  12. customto give an oily residue (4.95 g.), which
  13. washElution
  14. additionthe fractions containing a desired compound
  15. customwere collected
  16. customThe solvent was removed by distillation from the solution under reduced pressure

Sources & evidence

ORD record
ord-7e2ba7c9d6254c1a8d42727d0740ec26
Source dataset
uspto-grants-1980_01
Patent number
US04181800

Reaction notes

Loading…