Benzene → HCID 86736765, compound

Participants

Reaction Steps

Methyl 2-(4-formyl-2-oxo-3-phthalimido-1-azetidinyl)-2-phenylacetate (390 mg.) and O-benzyl hydroxylamine (170 mg.) were dissolved in dried benzene (10 ml), and the solution was stirred at ambient temperature for 4 hours and then heated at 50° to 60° C. for an hour. The reaction mixture was washed with 1% hydrochloric acid (10 ml.), water and an aqueous sodium chloride and then dried over magnesium sulfate. The solution was evaporated to dryness under reduced pressure to give a residue (560 mg.), which was subjected to column chromatography on silica gel (15 g.). Elution was carried out with chloroform and the fractions containing a desired compound were collected. The solution was removed by distillation from the solution under reduced pressure to give methyl 2-(4-benzyloxyimino-methyl-2-oxo-3-phthalimido-1-azetidinyl)-2-phenylacetate (530 mg.).

Provenance & Evidence