Formaldehyde → HCID 20377981, compound

HRID 2051708Notes

Reaction equation

HRID 2051708 reaction equation
[CH:1]([N:14]1[C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][N:16]=[CH:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]=[O:24]>>[CH:1]([N:14]1[C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][N:16]=[C:15]1[CH2:23][OH:24])([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 12798409HCID 12798409, compound

Product 1

HCID 20377981HCID 20377981, compound

Procedure

2.9 g (0.01 mol) of 1-benzhydryl-5-methoxycarbonyl-imidazole (Example 8) and 25 cc of 50% methanolic formaldehyde solution were heated for 36 hours to 135° C. 3.15 g of 1-benzhydryl-2-hydroxymethyl-5-methoxycarbonyl-imidazole, m.p. 160° C., were obtained from the reaction mixture in an almost quantitative yield.

Sources & evidence

ORD record
ord-ab483b6be43e4be99e0b95cb21c206e0
Source dataset
uspto-grants-1980_01
Patent number
US04182624

Reaction notes

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