Phosphine oxide, (chloromethyl)dimethyl- → HCID 20377999, compound

Participants

Reaction Steps

3.0 g (0.01 mol) of the sodium salt of 1-benzhydryl-5-imidazole-carboxylic acid (Example 11) and 1.8 g of chloromethyl dimethyl phosphine oxide were heated with 40 cc of dimethyl formamide to 120° C. under a nitrogen atmosphere until the reaction was completed. The solvent was removed under reduced presure and insoluble sodium chloride was separated by taking up the residue in acetone. Crystallization yielded colorless crystals melting at 174° C., Yield 3.2 g (88% of the theory).

Provenance & Evidence