HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2051712Generated: October 27, 2026
Chlorodiphenylmethane → 1-Benzhydryl-4,5-dimethoxycarbonyl-imidazole
https://huagongshe.com/reaction/2051712
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorodiphenylmethane | HCID 7035 | — |
| Reactant | 1H-Imidazole-4,5-dicarboxylic acid, 4,5-dimethyl ester | HCID 76810 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-Benzhydryl-4,5-dimethoxycarbonyl-imidazole | HCID 20377966 | — |
Reaction Steps
20.3 g of benzhydryl chloride were added dropwise to a suspension of 18.4 g (0.1 mol) of 4,5-dimethoxycarbonyl-imidazole in 60 cc of acetonitrile and 14 cc of triethylamine and the reaction mixture was heated for 8 hours at 80° C. The solvent was then removed under reduced pressure and triethylammonium chloride was separated by washing with water. 30 g (85% of the theory) of 1-benzhydryl-4,5-dimethoxycarbonyl-imidazole, m.p. 93° C., were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04182624 |
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| Source dataset | uspto-grants-1980_01 |
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| ORD ID | ord-ee7378ef8c724d6192d411b80f2b41cf |
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| Source note | uspto-grants-1980_01 |
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