HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl phosphite → Benzoic acid, 4-((6-(diethoxyphosphinyl)hexyl)oxy)-, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | Ethyl p-(6-Bromohexyloxy)benzoate | HCID 18989362 | — |
| Catalyst | Sodium Iodide | HCID 5238 | — |
| Product | Benzoic acid, 4-((6-(diethoxyphosphinyl)hexyl)oxy)-, ethyl ester | HCID 5271409 | — |
Reaction Steps
[I; Ar is 4-C2H5OOCC6H4, Y is O(CH2)6, R is C2H5 ] was prepared from 15 g of 6-(4-carbethoxyphenoxy)hexyl bromide, 8.3 g of triethyl phosphite and a crystal of sodium iodide as a catalyst, according to the procedure of Example 1, and had the b.p. 190°-196° C. (0.2 mm); yield 9.5 g; MIC vs. herpes simplex type 2=6 mcg/ml. The IR and NMR spectra were consistent with the assigned structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04182759 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-5cceb62e2c63432f8def4f3d425f43e1 |
| Source note | uspto-grants-1980_01 |