反应详情

0.92 g of 2-chloro-1H-naphth[2,3-d]imidazole and 0.57 g of 2-mercaptomethylpyridine were heated under reflux for 18 hours in 15 ml of ethanol and 4.5 ml of 1 N caustic soda. 50 ml of water were added to the reaction solution, which was then extracted twice with a total amount of 50 ml of ethyl acetate. The organic phases were washed with saturated sodium chloride solution, dried over magnesium sulphate, and evaporated to dryness on a rotary evaporator. Crystallisation from 50 ml of acetonitrile provided 0.68 g of 2-[(2-pyridylmethyl)thio]-1H-naphth[2,3-d]imidazole having a m.p. of 169°-170°.

1. extractionwas then extracted twice with a total amount of 50 ml of ethyl acetate
2. washThe organic phases were washed with saturated sodium chloride solution
3. dry with materialdried over magnesium sulphate
4. customevaporated to dryness on a rotary evaporator
5. customCrystallisation from 50 ml of acetonitrile