Formic Acid → N-(2-Benzoyl-4-chlorophenyl)formamide

HRID 2051776Notes

Reaction equation

HRID 2051776 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[CH:17](O)=[O:18]>>[C:4]([C:3]1[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:2]=1[NH:1][CH:17]=[O:18])(=[O:5])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 128702-Amino-5-chlorobenzophenone

Product 1

HCID 82576N-(2-Benzoyl-4-chlorophenyl)formamideYield 93%

Procedure

A mixture of 100 g (0.43 mole) of 2-amino-5-chlorobenzophenone and 500 g formic acid was refluxed for 1 hr, and then cooled and poured into 1 l. of ice water. The solid that precipitated was collected on a filter, washed with water, dried in air, and recrystallized from heptane-benzene to give 103.5 g (93%) of the formamide as colorless crystals, mp 89°-91°.

Workup

  1. temperaturewas refluxed for 1 hr
  2. temperaturecooled
  3. additionpoured into 1 l
  4. customThe solid that precipitated
  5. customwas collected on a filter
  6. washwashed with water
  7. customdried in air
  8. customrecrystallized from heptane-benzene

Sources & evidence

ORD record
ord-c3fd0cb660f64c7fa657c58979406a5e
Source dataset
uspto-grants-1980_01
Patent number
US04182760

Reaction notes

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