Ethyl Acetate → HCID 54470639, compound

Participants

Reaction Steps

A mixture of 3.6 g of D-glucose and a 10% methylamine-methanol solution is heated at 60° C. for 20 minutes in a sealed tube. The reaction mixture is condensed to dryness under reduced pressure, whereby 3.8 g of 1-methylamino-1-deoxy-D-glucose are obtained as a crude product. 3.8 g of said crude product are dissolved in 40 ml of methanol, and a solution of 2.5 g of 2-chloroethyl isocyanate in 10 ml of tetrahydrofuran is added dropwise thereto at 0° to 5° C. The solution is stirred at the same temperature for 1.5 hours. Then, the reaction solution is condensed under reduced pressure, and a mixture of ethyl acetate and ether is added to the residue. 4.5 g of 1-(2-chloroethyl)-3-methyl-3-D-glucopyranosylurea are thereby obtained as colorless caramel.

Provenance & Evidence