Sodium Nitrite → HCID 54358429, compound

HRID 2051810Notes

Reaction equation

HRID 2051810 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH2:19][CH2:20][CH3:21])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:22]([O-])=[O:23].[Na+]>C(O)=O>[Cl:1][CH2:2][CH2:3][N:4]([N:22]=[O:23])[C:5]([N:7]([CH2:19][CH2:20][CH3:21])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 54055120HCID 54055120, compound

Product 1

HCID 54358429HCID 54358429, compoundYield 27.6%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

6.0 g of 1-(2-chloroethyl)-3-n-propyl-3-D-galactopyranosylurea are dissolved in 15 ml of formic acid, and 4.2 g of sodium nitrite are added gradually thereto at 0° to 5° C. for one hour under stirring. The mixture is further strirred at the same temperature for one hour. After the reaction, the mixture is treated in the same manner as described in Example 5-(2). 1.8 g of 1-(2-chloroethyl)-1-nitroso-3-n-propyl-3-D-galactopyranosylurea are thereby obtained as pale yellow caramel.

Workup

  1. waitThe mixture is further strirred at the same temperature for one hour
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

Sources & evidence

ORD record
ord-21929d0785ac4fd5b99d56d295c4affa
Source dataset
uspto-grants-1980_01
Patent number
US04182757

Reaction notes

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