Sodium Carbonate → HCID 54358429, compound

Participants

Reaction Steps

3.3 g of 1-(2-chloroethyl)-3-n-propyl-3-D-galactopyranosylurea are dissolved in a mixture of 60 ml of tetrahydrofuran and 60 ml of methylene chloride, and 15 g of sodium carbonate anhydrate are added thereto. 5 g of nitrogen tetroxide gas are introduced into the mixture for 10 minutes under ice-cooling. The mixture is treated in the same manner as described in Example 2. 2.8 g of 1-(2-chloroethyl)-1-nitroso-3-n-propyl-3-D-galactopyranosylurea are thereby obtained as pale yellow caramel. [α]D23 +18.0°(C=1.0, methanol)

Provenance & Evidence