Sodium Nitrite → HCID 53655759, compound

HRID 2051813Notes

Reaction equation

HRID 2051813 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH:19]([CH3:21])[CH3:20])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:22]([O-])=[O:23].[Na+]>C(O)=O>[Cl:1][CH2:2][CH2:3][N:4]([N:22]=[O:23])[C:5]([N:7]([CH:19]([CH3:21])[CH3:20])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 54461744HCID 54461744, compound

Product 1

HCID 53655759HCID 53655759, compoundYield 27.6%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

6.0 g of 1-(2-chloroethyl)-3-isopropyl-3-D-galactopyranosylurea are dissolved in 20 ml of formic acid, and 4.2 g of sodium nitrite are added gradually thereto at 0° to 5° C. for one hour under stirring. The mixture is further stirred at the same temperature for one hour. After the reaction, the mixture is treated in the same manner as described in Example 5-(2). 1.8 g of 1-(2-chloroethyl)-1-nitroso-3-isopropyl-3-D-galactopyranosylurea are thereby obtained as pale yellow caramel.

Workup

  1. stirringThe mixture is further stirred at the same temperature for one hour
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

Sources & evidence

ORD record
ord-86b79abd1ca44bc7b0f2215ce0f0b2a4
Source dataset
uspto-grants-1980_01
Patent number
US04182757

Reaction notes

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