Sodium Nitrite → HCID 53734507, compound

HRID 2051815Notes

Reaction equation

HRID 2051815 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH2:19][CH2:20][CH2:21][CH3:22])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:23]([O-])=[O:24].[Na+]>C(O)=O>[Cl:1][CH2:2][CH2:3][N:4]([N:23]=[O:24])[C:5]([N:7]([CH2:19][CH2:20][CH2:21][CH3:22])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 53937512HCID 53937512, compound

Product 1

HCID 53734507HCID 53734507, compoundYield 34.6%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

4.8 g of 1-(2-chloroethyl)-3-n-butyl-3-D-galactopyranosylurea are dissolved in 15 ml of formic acid, and 2.4 g of sodium nitrite are added gradually thereto at 0° to 5° C. for one hour under stirring. The mixture is further stirred at the same temperature for 1.5 hours. After the reaction, the mixture is treated in the same manner as described in Example 5-(2). 1.8 g of 1-(2-chloroethyl)-1-nitroso-3-n-butyl-3-D-galactopyranosylurea are thereby obtained as a yellow powder.

Workup

  1. stirringThe mixture is further stirred at the same temperature for 1.5 hours
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

Sources & evidence

ORD record
ord-58fa17e16c1b49a08d7a964cd32d2886
Source dataset
uspto-grants-1980_01
Patent number
US04182757

Reaction notes

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